Протеоміка активації Т-лімфоцитів мишей, позбавлених гена pttg

Abstract

T lymphocytes play a key role in functioning the immune systems of a man and other mammals. We found 18 proteins, whose expression was changed in pttg-knockout T lymphocytes as compared with wild-type T lymphocytes. We showed that pttg-knockout was accompanied by a decreased expression of interleukin-4 and an enhanced expression of interferon-gamma in activated T lymphocytes.