Стабильность генома высокопродуктивных клеточных линий раувольфии змеиной при длительном выращивании in vitro

Abstract

Genetic analysis of the tissues from long-term cultured Rauwolfia serpentina cell lines has been carried out through RAPD-analysis. RAPD-markers used were found to allow differentiating the involved strains. The established strains were shown to maintain the genetic stability for a long time upon the growth under standard conditions. A change in culture conditions and the medium composition, in particular, may induce genome alterations in cells of the established strain.