Математична модель участi титiну у циклi процесiв скорочення скелетних м’язiв

Abstract

A model describing the titin contribution in skeletal muscle force generation is suggested. Our model assumes that titin aggregates with myosin with some curvature. The main assumption is that the effective length of titin (the length of a part non-aggregated with myosin and left in spiral form) is shortened, and the spiral of titin PEVK domains is unrolled, these quantities being changed proportionally. The formula for a titin contribution in the “force-length” dependence of skeletal muscle is obtained.