Экспериментальное изучение развития толерантности к циназепаму

Abstract

We have studied the development of tolerance to the hypnotic, sedative, and motor coordination activities of cinazepam under its durable administration for 14 and 30 days to mice. The durable cinazepam administation for 30 days in a doze of 0.4 mg/kg (ED50) conserves the hypnotyc activity, while the tolerance to the motor coordination and sedative effects is developed.