Експресія симпортера натрію/йоду (NIS) в післячорнобильських фолікулярних аденомах щитовидної залози

Abstract

The expression of NIS protein by immunohistochemistry with the use of a specific monoclonal antibody in 24 post-Chernobyl thyroid follicular adenomas surrounding by normal tissues is studied. It is shown that thyroid follicular adenomas are characterized by heterogeneity as for the expression and localization of NIS. The part of tumors (37.5%) shows the diffuse or local increase of membrane’s NIS expression. Nearly in a half of adenomas (45.8%), the immunohi-stochemical reaction was absent. Localization of NIS in cytoplasm was detected only in oxyphilic cells adenomas.