TNFα receptor1 drives hypoxia-promoted invasiveness of human melanoma cells

dc.contributor.authorMarconi C.
dc.contributor.authorPeppicelli S.
dc.contributor.authorBianchini F.
dc.contributor.authorCalorini L.
dc.date.accessioned2019-01-19T16:38:55Z
dc.date.available2019-01-19T16:38:55Z
dc.date.issued2013
dc.description.abstractAim: Oxygen deprivation leading to hypoxia represents a common feature of advanced solid tumors, able to control several aspects of tumor progression. Indeed, ability to respond to changes in oxygen partial pressure represents a hallmark of malignant cells. Aim of this study is to disclose new pathway of hypoxia-induced tumor cell invasion. Materials and Methods: Hs294T human melanoma cells were grown in a gas mixture containing 0.3 % , and used to evaluate invasion on Matrigel-coated polycarbonate filters mounted in Boyden's chambers, MMP release and expression of inflammatory receptors and their ligands. Results: We demonstrate that hypoxia promotes the expression of TNFa receptor 1 (TNFαR1) able to drive a higher ability to penetrate Matrigel-coated filters of Hs294T human melanoma cells, an effect does not mediated by hypoxia-inducible factor (HIF)-1α. Conclusion: Expression inflammatory cytokine receptors in hypoxic human melanoma cells might provide a new target for improving strategies against local and distant tumor cell diffusion. Key Words: TNFa receptor 1, Hs294T human melanoma cells, hypoxia, cell invasiveness, metalloproteinase 2 and 9.uk_UA
dc.description.sponsorshipThis work was supported by grants from Ente Cassa di Risparmio di Firenze (ECRF) and Instituto Toscano Tumori (ITT).uk_UA
dc.identifier.citationTNFα receptor1 drives hypoxia-promoted invasiveness of human melanoma cells / C. Marconi, S. Peppicelli, F. Bianchini, L. Calorini // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 187-191. — Бібліогр.: 24 назв. — англ.uk_UA
dc.identifier.issn1812-9269
dc.identifier.urihttps://nasplib.isofts.kiev.ua/handle/123456789/145228
dc.language.isoenuk_UA
dc.publisherІнститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН Україниuk_UA
dc.relation.ispartofExperimental Oncology
dc.statuspublished earlieruk_UA
dc.subjectOriginal contributionsuk_UA
dc.titleTNFα receptor1 drives hypoxia-promoted invasiveness of human melanoma cellsuk_UA
dc.typeArticleuk_UA

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