TNFα receptor1 drives hypoxia-promoted invasiveness of human melanoma cells
dc.contributor.author | Marconi C. | |
dc.contributor.author | Peppicelli S. | |
dc.contributor.author | Bianchini F. | |
dc.contributor.author | Calorini L. | |
dc.date.accessioned | 2019-01-19T16:38:55Z | |
dc.date.available | 2019-01-19T16:38:55Z | |
dc.date.issued | 2013 | |
dc.description.abstract | Aim: Oxygen deprivation leading to hypoxia represents a common feature of advanced solid tumors, able to control several aspects of tumor progression. Indeed, ability to respond to changes in oxygen partial pressure represents a hallmark of malignant cells. Aim of this study is to disclose new pathway of hypoxia-induced tumor cell invasion. Materials and Methods: Hs294T human melanoma cells were grown in a gas mixture containing 0.3 % , and used to evaluate invasion on Matrigel-coated polycarbonate filters mounted in Boyden's chambers, MMP release and expression of inflammatory receptors and their ligands. Results: We demonstrate that hypoxia promotes the expression of TNFa receptor 1 (TNFαR1) able to drive a higher ability to penetrate Matrigel-coated filters of Hs294T human melanoma cells, an effect does not mediated by hypoxia-inducible factor (HIF)-1α. Conclusion: Expression inflammatory cytokine receptors in hypoxic human melanoma cells might provide a new target for improving strategies against local and distant tumor cell diffusion. Key Words: TNFa receptor 1, Hs294T human melanoma cells, hypoxia, cell invasiveness, metalloproteinase 2 and 9. | uk_UA |
dc.description.sponsorship | This work was supported by grants from Ente Cassa di Risparmio di Firenze (ECRF) and Instituto Toscano Tumori (ITT). | uk_UA |
dc.identifier.citation | TNFα receptor1 drives hypoxia-promoted invasiveness of human melanoma cells / C. Marconi, S. Peppicelli, F. Bianchini, L. Calorini // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 187-191. — Бібліогр.: 24 назв. — англ. | uk_UA |
dc.identifier.issn | 1812-9269 | |
dc.identifier.uri | https://nasplib.isofts.kiev.ua/handle/123456789/145228 | |
dc.language.iso | en | uk_UA |
dc.publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України | uk_UA |
dc.relation.ispartof | Experimental Oncology | |
dc.status | published earlier | uk_UA |
dc.subject | Original contributions | uk_UA |
dc.title | TNFα receptor1 drives hypoxia-promoted invasiveness of human melanoma cells | uk_UA |
dc.type | Article | uk_UA |
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