Экспрессия онкобелка Е6 вируса папилломы человека в эпителии придатков матки при раке яичника и генетической предрасположенности к нему

Abstract

Проведено комплексное морфологическое и иммуногистохимиче- ское исследование придатков матки у 20 женщин с генетической предрас- положенностью к развитию рака яичников (РЯ) и 55 больных РЯ. У 60,0% женщин с высоким риском РЯ выявлена экспрессия онкобелка Е6 вируса па- пилломы человека (ВПЧ)16 и18 типов в эпителии маточных труб, поверх- ностном эпителии яичников, гранулезных клетках фолликулов, эпителии фолликулярных кист и эндотелии сосудов. У 16,3% больных РЯ установлено наличие вирусного онкобелка в опухолевых клетках. Экспрессия опухолево- го супрессора р53 отсутствовала в ткани инфицированных ВПЧ яичников женщин с высоким риском РЯ и была достоверно ниже в ВПЧ-позитивном РЯ по сравнению с ВПЧ-негативными опухолями. Предполагается, что па- пилломавирусная инфекция может являться дополнительным экзогенным фактором злокачественной трансформации эпителия яичников. Ключевые слова: рак яичника, онкобелок Е6, вирус папилломы человека, р53, генетическая предрасположенность к раку.

Complex morphological and immunohisto chemical study of adnexa uteri in 20 women with genetic predisposition to ovarian cancer (OC) and 55 OC patients was carried out. The presence of HPV 16/18 E6 oncoprotein in epithelial lining of fallopian tubes, ovarian surface epithelium, granulose cells of follicules, epithelium of follicular cysts and endothelial cells was revealed in 60% of women at high risk of developing OC. Tumor cells of 16,3% of OC patients were also positive for HPV 16/18 E6 oncoprotein. Expression of tumor suppressor protein p53 was absent in HPV-positive ovarian tissues in women at high risk of developing ovarian cancer and was significantly lower in HPV-positive OC compared to HPV-negative tumors. It is assumed that papillomavirus infection can be an addition exogenous inductor of malignant transformation of ovarian epithelium. Complex morphological and immunohisto chemical study of adnexa uteri in 20 women with genetic predisposition to ovarian cancer (OC) and 55 OC patients was carried out. The presence of HPV 16/18 E6 oncoprotein in epithelial lining of fallopian tubes, ovarian surface epithelium, granulose cells of follicules, epithelium of follicular cysts and endothelial cells was revealed in 60% of women at high risk of developing OC. Tumor cells of 16,3% of OC patients were also positive for HPV 16/18 E6 oncoprotein. Expression of tumor suppressor protein p53 was absent in HPV-positive ovarian tissues in women at high risk of developing ovarian cancer and was significantly lower in HPV-positive OC compared to HPV-negative tumors. It is assumed that papillomavirus infection can be an addition exogenous inductor of malignant transformation of ovarian epithelium.Complex morphological and immunohisto chemical study of adnexa uteri in 20 women with genetic predisposition to ovarian cancer (OC) and 55 OC patients was carried out. The presence of HPV 16/18 E6 oncoprotein in epithelial lining of fallopian tubes, ovarian surface epithelium, granulose cells of follicules, epithelium of follicular cysts and endothelial cells was revealed in 60% of women at high risk of developing OC. Tumor cells of 16,3% of OC patients were also positive for HPV 16/18 E6 oncoprotein. Expression of tumor suppressor protein p53 was absent in HPV-positive ovarian tissues in women at high risk of developing ovarian cancer and was significantly lower in HPV-positive OC compared to HPV-negative tumors. It is assumed that papillomavirus infection can be an addition exogenous inductor of malignant transformation of ovarian epithelium.Complex morphological and immunohisto chemical study of adnexa uteri in 20 women with genetic predisposition to ovarian cancer (OC) and 55 OC patients was carried out. The presence of HPV 16/18 E6 oncoprotein in epithelial lining of fallopian tubes, ovarian surface epithelium, granulose cells of follicules, epithelium of follicular cysts and endothelial cells was revealed in 60% of women at high risk of developing OC. Tumor cells of 16,3% of OC patients were also positive for HPV 16/18 E6 oncoprotein. Expression of tumor suppressor protein p53 was absent in HPV-positive ovarian tissues in women at high risk of developing ovarian cancer and was significantly lower in HPV-positive OC compared to HPV-negative tumors. It is assumed that papillomavirus infection can be an addition exogenous inductor of malignant transformation of ovarian epithelium. Key Words: ovarian cancer, oncoprotein Е6, human papillomavirus, р53, genetic susceptibility to cancer.