The phenomenon of multi-drug resistance in the treatment of malignant tumors

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dc.contributor.authorVtorushin, S.V.
dc.contributor.authorKhristenko, K.Y.
dc.contributor.authorZavyalova, M.V.
dc.contributor.authorPerelmuter, V.M.
dc.contributor.authorLitviakov, N.V.
dc.contributor.authorDenisov, E.V.
dc.contributor.authorDulesova, A.Y.
dc.contributor.authorCherdyntseva, N.V.
dc.date.accessioned2019-01-20T20:49:24Z
dc.date.available2019-01-20T20:49:24Z
dc.date.issued2014
dc.description.abstractMulti-drug resistance (MDR) is a condition when there is broad cross-resistance of cells to various agents which are different in structure and effect. Modern perceptions on mechanisms of MDR development in malignant tumors have been considered, in particular, in tre­ating breast cancer. Physiological functions and contribution to MDR development of ABC-transporter protein families have been described. The role of activation of glutathione system enzymes and apoptosis-regulating proteins in MDR formation has been shown. Key Words: multi-drug resistance, ABC-transporters, glutathione system, apoptosis-controlling genes.uk_UA
dc.description.sponsorshipThe study is supported by the grants № 14–04– 31727/14 and № 13–04–98111 r_Sibir_a of Russian Foundation of Basic Research (RFBR) and Grant of the President of the Russian Federation (agreement 14.122.13.491-MD).uk_UA
dc.identifier.citationThe phenomenon of multi-drug resistance in the treatment of malignant tumors / S.V. Vtorushin, K.Y. Khristenko, M.V. Zavyalova, V.M. Perelmuter, N.V. Litviakov, E.V. Denisov, A.Y. Dulesova, N.V. Cherdyntseva // Experimental Oncology. — 2014. — Т. 36, № 3. — С. 144-156. — Бібліогр.: 191 назв. — англ.uk_UA
dc.identifier.issn1812-9269
dc.identifier.urihttps://nasplib.isofts.kiev.ua/handle/123456789/145358
dc.language.isoenuk_UA
dc.publisherІнститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН Україниuk_UA
dc.relation.ispartofExperimental Oncology
dc.statuspublished earlieruk_UA
dc.subjectReviewsuk_UA
dc.titleThe phenomenon of multi-drug resistance in the treatment of malignant tumorsuk_UA
dc.typeArticleuk_UA

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Experimental Oncology, 2014, № 3