The study of mismatch repair in endometrial cancer patients with a family history of cancer

dc.contributor.authorBuchynska, L.G.
dc.contributor.authorBrieieva, O.V.
dc.contributor.authorNekrasov, K.A.
dc.contributor.authorNespryadko, S.V.
dc.date.accessioned2019-01-23T18:23:28Z
dc.date.available2019-01-23T18:23:28Z
dc.date.issued2015
dc.description.abstractAim: To assess the expression of mismatch repair (MMR) proteins MSH2 and MLH1 and carry out microsatellite analysis in patients with endometrial cancer (EC) with regard to the family history of cancer. Materials and Methods: Morphological and immunohistochemical study was performed on tumor tissue samples of 49 EC patients. Microsatellite instability was determined using PCR with primers which flank microsatellite region BAT-26. Results: A tendency to a decreased expression of both MSH2 and MLH1 markers in a group of EC patients with a family history of cancer as compared with a group without aggregation of cancer in family history was observed (labeling index — LI — was 36.1 ± 8.1% and LI 20.7 ± 9.1% versus LI 48.0 ± 5.8% and 33.8 ± 5.8%, respectively). It was determined that the number of EC patients with tumors deficient by expression of MMR markers was reliably higher in a group of patients with a family history of cancer than in a group of patients without aggregation of cancer in fami­ly history (р < 0.05). It was shown that in a group of EC patients with a family history of cancer, MMR-proficient tumors were detected in 38.5% of cases. Microsatellite instability was determined in 10.7% of EC patients including one patient with aggregation of Lynch-associated tumors in family history. Conclusion: Family history of cancer of EC patients is associated with malfunctioning of the MMR system as well as may be related to alternative molecular mechanisms. Key Words: endometrial cancer, mismatch repair, microsatellite instability, family history of cancer, Lynch syndrome.uk_UA
dc.identifier.citationThe study of mismatch repair in endometrial cancer patients with a family history of cancer / L.G. Buchynska, O.V. Brieieva, K.A. Nekrasov, S.V. Nespryadko // Experimental Oncology. — 2015. — Т. 37, № 4. — С. 272-276. — Бібліогр.: 33 назв. — англ.uk_UA
dc.identifier.issn1812-9269
dc.identifier.urihttps://nasplib.isofts.kiev.ua/handle/123456789/145555
dc.language.isoenuk_UA
dc.publisherІнститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН Україниuk_UA
dc.relation.ispartofExperimental Oncology
dc.statuspublished earlieruk_UA
dc.subjectOriginal contributionsuk_UA
dc.titleThe study of mismatch repair in endometrial cancer patients with a family history of canceruk_UA
dc.typeArticleuk_UA

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