Вплив піридину на активність мембранозв’язаних ферментів клітин печінки

Abstract

Pyridine does not provoke significant changes of the ecto-ATPase and 5′-nucleotidase activities of the plasma membrane of hepatocytes. Mg2+, Ca2+-ATPase activity is not changed under the influence of pyridine too. Pyridine produces the alterations of the Na+, K+-ATPase activity that have biphase character. A decrease of the enzyme activity is observed at nanomolar and 10−5 M concentrations and disappears at micromolar concentrations. This effect might be caused by features of the pyridine interaction with the membrane lipid matrix.