Формализованный анализ адаптивного реагирования клетки на дефицит энергии

Abstract

To find causal relations between the cellular energy, alterations of mitochondria, and the cellular mechanism of reactive adaptation (MRA) under exogenous stimuli, a formal analysis is performed. It is shown that there are four main consumers (biosynthesis, homeostasis, reparative and compensatory syntheses) of cell energy. Violating the cellular homeostasis, the exogenous factors decrease the part of energy necessary to provide the biosynthesis. Intermediate chemical agents of the strangulated biosynthesis activate a cascade of transformations leading to an enlargement of both the mitochondrial power and the energy production intensity. This negative feed-back contour is the essence of MRA that maintains the process of decentralized adaptation of a multicellular organism to environmental shifts.